TABLA VII. Distribución de frecuencias genotípicas de los polimorfismos de IL13, IL4RA, IL5 y B2AR
|
Polimorfismo |
Genotipos |
Pacientes |
Controles |
Asma |
Rinitis |
p valor
|
|
|
|
|
n (%) |
n (%) |
n (%) |
ControlesvsPacientes |
AsmavsRinitis |
|
IL13 C-1112T |
CC |
49 (33.6) |
17 (34) |
36 (33.0) |
13 (35.1) |
|
NS |
|
|
CT |
71 (48.6) |
14 (28) |
53 (48.6) |
18 (48.6) |
|
|
|
|
TT |
26 (17.8) |
19 (38) |
20 (18.3) |
6 (16.2) |
0.006 OR 0.35 a* (0.16-0.76) |
NS |
|
|
|||||||
IL13 R130Q |
RR |
87 (60.0) |
41 (82) |
68 (63.0) |
19 (51.4) |
|
NS |
|
|
RQ |
54 (37.2) |
8 (16) |
38 (35.1) |
16 (43.2) |
0.009 OR 3.12 a† (1.29-7.79) |
NS |
|
|
|
4 (2.8) |
1(2) |
2 (1.9) |
2 (54.0) |
|
|
|
|
|
|
|
|
|
|
|
IL4RA I50V |
II |
45 (30.8) |
16 (32) |
35 (32.1) |
10 (27.0) |
NS |
NS |
|
|
IV |
77 (52.7) |
23 (46) |
52 (47.7) |
25 (67.6) |
|
|
|
|
VV |
24 (16.4) |
11 (22) |
22 (20.2) |
2 (5.4) |
|
|
|
|
|||||||
IL4RA Q551R |
|
90 (61.6) |
34 (68) |
69 (63.3) |
21 (56.8) |
NS |
NS |
|
|
QR |
50 (34.2) |
14 (28) |
37 (33.9) |
13 (35.1) |
|
|
|
|
RR |
6 (4.1) |
2 (4) |
3 (2.8) |
3 (8.1) |
|
|
|
|
|||||||
IL5 C–746T |
CC |
62 (42.5) |
22 (44) |
44 (40.4) |
18 (48.6) |
NS |
NS |
|
|
CT |
69 (47.3) |
22 (44) |
57 (52.3) |
12 (32.4) |
|
|
|
|
TT |
15 (10.3) |
6 (12) |
8 (7.3) |
7 (18.9) |
|
0.045 OR 0.34 b‡ (0.1-1.15) |
|
|
|
|
|
|
|
|
|
B2AR R16G |
RR |
24 (16.6) |
8 (16) |
17 (15.7) |
7 (18.9) |
NS |
NS |
|
|
GR |
72 (49.7) |
25 (50) |
54 (50.0) |
18 (48.6) |
|
|
|
|
GG |
49 (33.8) |
17 (34) |
37 (34.3) |
12 (32.4) |
|
|
|
|
|||||||
|
B2AR Q27E |
|
62 (43) |
24 (48) |
49 (45.8) |
13 (35.1) |
NS |
NS |
|
|
QE |
59 (41) |
22 (44) |
40 (37.4) |
19 (51.4) |
|
|
|
|
EE |
23 (16) |
4 (8) |
18 (16.8) |
5 (13.5) |
|
|
|
|
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